| Protein Name |
Bcl-2 homologous antagonist/killer |
| #PDB ID |
1
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
Q16611 (BAK_HUMAN)
|
| Synonym(s) |
- BCL2-like 7 protein
- apoptosis regulator BAK
- bcl-2-like protein 7
- bcl2-L-7
- pro-apoptotic protein BAK
- BAK
- BAK-LIKE
- BCL2L7
- CDN1
show 8 synonym(s)
|
| Gene Symbol |
BAK1
|
| Gene ID |
578
|
| Sequence |
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS |
| Protein Class |
CELL CYCLE |
| Function |
Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases.
|
