Protein |
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| Protein Name | Bcl-2-like protein 1 | |||||
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| #PDB ID | 1 | |||||
| Organism | Homo sapiens (Human) | |||||
| Uniprot ID/ACC | Q07817 (B2CL1_HUMAN) | |||||
| Synonym(s) |
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| Gene Symbol | BCL2L1 | |||||
| Gene ID | 598 | |||||
| Sequence | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK | |||||
| Protein Class | SIGNALING PROTEIN | |||||
| Function | Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(S) promotes apoptosis. |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
| COVPDB1027 | KBH | 6RNU |
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SHOW |