| Protein Name |
3-oxoacyl-[acyl-carrier-protein] synthase 3 |
| #PDB ID |
3
|
| Organism |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Uniprot ID/ACC |
P9WNG3 (FABH_MYCTU)
|
| Synonym(s) |
- beta-ketoacyl-ACP synthase III
- MCAN_RS02780
- MCAN_05361
show 2 synonym(s)
|
| Gene Symbol |
fabH
|
| Gene ID |
45424497
|
| Sequence |
MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDESAASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG |
| Protein Class |
TRANSFERASE |
| Function |
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Possesses a clear preference for long-chain acyl-CoA substrates rather than acyl-ACP primers, and shows only weak activity with acetyl-CoA. Its substrate specificity determines the biosynthesis of mycolic acid fatty acid chain, which is characteristic of mycobacterial cell wall.
|
