Protein
Protein Name Fatty-acid amide hydrolase 1
#PDB ID 10
Organism Rattus norvegicus (Rat)
Uniprot ID/ACC P97612 (FAAH1_RAT)
Synonym(s)
  •   anandamide amidase
  • anandamide amidohydrolase 1
  • fatty acid ester hydrolase
  • oleamide hydrolase 1
show 3 synonym(s)
Gene Symbol Faah
Gene ID 100911581
Sequence MVLSEVWTTLSGVSGVCLACSLLSAAVVLRWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS
Protein Class HYDROLASE
Function Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:9299394, PubMed:9790682, PubMed:10526230, PubMed:11128635, PubMed:15533037, PubMed:17649977). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:11128635). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:10526230, PubMed:15533037, PubMed:17649977). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity).
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB578 BR1 4J5P Ki : 12 nM PDBBind SHOW
COVPDB781 F27 3K83 Ki : 22 nM, IC50 : 6 nM BindingDB SHOW
COVPDB781 F27 3K83 Ki : 22 nM Binding MOAD SHOW
COVPDB782 F2C 3K7F Ki : 14.5 nM, IC50 : 100 nM, Ki : 10.3 nM, Ki : 26 nM, Ki : 20 nM, Ki : 10.4 nM BindingDB SHOW
COVPDB986 JG2 3PR0 Ki : 0.29 nM PDBBind SHOW
COVPDB1012 K84 3K84 IC50 : 4 nM, Ki : 3 nM BindingDB SHOW
COVPDB1180 OHO 3LJ7 IC50 : 4.6 nM PDBBind SHOW
COVPDB1183 OJ8 3OJ8 Kd : 4.4 nM PDBBind SHOW
COVPDB1297 S99 2WJ1 Ki : 1.9 nM PDBBind SHOW
COVPDB1224 PIX 3LJ6
-
-
SHOW
COVPDB1180 OHO 4DO3
-
-
SHOW