Protein |
||||||
Protein Name | Fatty-acid amide hydrolase 1 | |||||
---|---|---|---|---|---|---|
#PDB ID | 10 | |||||
Organism | Rattus norvegicus (Rat) | |||||
Uniprot ID/ACC | P97612 (FAAH1_RAT) | |||||
Synonym(s) |
|
|||||
Gene Symbol | Faah | |||||
Gene ID | 100911581 | |||||
Sequence | MVLSEVWTTLSGVSGVCLACSLLSAAVVLRWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS | |||||
Protein Class | HYDROLASE | |||||
Function | Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:9122178, PubMed:9299394, PubMed:9790682, PubMed:10526230, PubMed:11128635, PubMed:15533037, PubMed:17649977). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:9122178, PubMed:11128635). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:10526230, PubMed:15533037, PubMed:17649977). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity). |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
COVPDB578 | BR1 | 4J5P | Ki : 12 nM | PDBBind | SHOW | |
COVPDB781 | F27 | 3K83 | Ki : 22 nM, IC50 : 6 nM | BindingDB | SHOW | |
COVPDB781 | F27 | 3K83 | Ki : 22 nM | Binding MOAD | SHOW | |
COVPDB782 | F2C | 3K7F | Ki : 14.5 nM, IC50 : 100 nM, Ki : 10.3 nM, Ki : 26 nM, Ki : 20 nM, Ki : 10.4 nM | BindingDB | SHOW | |
COVPDB986 | JG2 | 3PR0 | Ki : 0.29 nM | PDBBind | SHOW | |
COVPDB1012 | K84 | 3K84 | IC50 : 4 nM, Ki : 3 nM | BindingDB | SHOW | |
COVPDB1180 | OHO | 3LJ7 | IC50 : 4.6 nM | PDBBind | SHOW | |
COVPDB1183 | OJ8 | 3OJ8 | Kd : 4.4 nM | PDBBind | SHOW | |
COVPDB1297 | S99 | 2WJ1 | Ki : 1.9 nM | PDBBind | SHOW | |
COVPDB1224 | PIX | 3LJ6 |
- |
- |
SHOW | |
COVPDB1180 | OHO | 4DO3 |
- |
- |
SHOW |