COVPDB

Protein
Protein Name	Beta-secretase 1
#PDB ID	3
Organism	Homo sapiens (Human)
Uniprot ID/ACC	P56817 (BACE1_HUMAN)
Synonym(s)	APP beta-secretase asp 2 aspartyl protease 2 beta-secretase 1 precursor variant 1 beta-site APP cleaving enzyme 1 beta-site APP-cleaving enzyme beta-site amyloid beta A4 precursor protein-cleaving enzyme memapsin-2 membrane-associated aspartic protease 2 transmembrane aspartic proteinase Asp2 ASP2 BACE HSPC104 show 12 synonym(s)
Gene Symbol	BACE1
Gene ID	23621
Sequence	MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
Protein Class	HYDROLASE
Function	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, PubMed:20354142). Cleaves CHL1 (By similarity).