Protein
Protein Name Retinal dehydrogenase 1
#PDB ID 2
Organism Ovis aries (Sheep)
Uniprot ID/ACC P51977 (AL1A1_SHEEP)
Synonym(s)
  •   ALDH-E1
  • ALHDII
  • RALDH 1
  • aldehyde dehydrogenase family 1 member A1
  • aldehyde dehydrogenase
  • cytosolic
  • ralDH1
show 6 synonym(s)
Gene Symbol ALDH1A1
Gene ID 443343
Sequence MSSSAMPDVPAPLTNLQFKYTKIFINNEWHSSVSGKKFPVFNPATEEKLCEVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDRLLLATMEAMNGGKLFSNAYLMDLGGCIKTLRYCAGWADKIQGRTIPMDGNFFTYTRSEPVGVCGQIIPWNFPLLMFLWKIGPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQGVFYHQGQCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYEKILDLIESGKKEGAKLECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGIFTNDIDKAITVSSALQSGTVWVNCYSVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTIKISQKNS
Protein Class OXIDOREDUCTASE
Function Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:26373694).
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB1017 K9P 5AC1
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SHOW
COVPDB1017 K9P 5AC0
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SHOW