Protein
Protein Name Kallikrein-7
#PDB ID 6
Organism Homo sapiens (Human)
Uniprot ID/ACC P49862 (KLK7_HUMAN)
Synonym(s)
  •   kallikrein 7 (chymotryptic
  • stratum corneum)
  • serine protease 6
  • signal protein
  • stratum corneum chymotryptic enzyme
  • PRSS6
  • SCCE
  • hK7
show 7 synonym(s)
Gene Symbol KLK7
Gene ID 5650
Sequence MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
Protein Class HYDROLASE
Function May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB1011 K7J 2QXI
-
-
SHOW
COVPDB1011 K7J 2QXH
-
-
SHOW
COVPDB1062 SH7 6SHH
-
-
SHOW
COVPDB1011 K7J 2QXJ
-
-
SHOW
COVPDB1062 LFW 6SJU
-
-
SHOW
COVPDB1307 SH8 6SHI
-
-
SHOW