Protein
Protein Name 14-3-3 protein sigma
#PDB ID 11
Organism Homo sapiens (Human)
Uniprot ID/ACC P31947 (1433S_HUMAN)
Synonym(s)
  •   epithelial cell marker protein 1
  • YWHAS
show 1 synonym(s)
Gene Symbol SFN
Gene ID 2810
Sequence MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADNAGEEGGEAPQEPQS
Protein Class SIGNALING PROTEIN
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. p53-regulated inhibitor of G2/M progression.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB832 G4Z 6HHP
-
-
SHOW
COVPDB1037 KM8 6RWU
-
-
SHOW
COVPDB856 GF8 6HN2
-
-
SHOW
COVPDB1037 KM8 6SLX
-
-
SHOW
COVPDB852 GE8 6HMU
-
-
SHOW
COVPDB999 JT2 6R5L
-
-
SHOW
COVPDB842 G8Q 6HKB
-
-
SHOW
COVPDB843 G8T 6HKF
-
-
SHOW
COVPDB853 GEH 6HMT
-
-
SHOW
COVPDB1036 KLZ 6RWS
-
-
SHOW
COVPDB999 JT2 6RJQ
-
-
SHOW