| Protein Name |
Interleukin-12 subunit beta |
| #PDB ID |
1
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
P29460 (IL12B_HUMAN)
|
| Synonym(s) |
- CLMF p40
- IL-12 subunit p40
- IL12
- subunit p40
- NK cell stimulatory factor chain 2
- cytotoxic lymphocyte maturation factor 40 kDa subunit
- interleukin 12
- p40
- interleukin 12B (natural killer cell stimulatory factor 2
- cytotoxic lymphocyte maturation factor 2
- p40)
- interleukin-12 beta chain
- natural killer cell stimulatory factor
- 40 kD subunit
- CLMF
- CLMF2
- IL-12B
- IMD28
- IMD29
- NKSF
- NKSF2
show 20 synonym(s)
|
| Gene Symbol |
IL12B
|
| Gene ID |
3593
|
| Sequence |
MCHQQLVISWFSLVFLASPLVAIWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWSEWASVPCS |
| Protein Class |
SIGNALING PROTEIN |
| Function |
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
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