Protein |
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Protein Name | Cathepsin S | |||||
---|---|---|---|---|---|---|
#PDB ID | 18 | |||||
Organism | Homo sapiens (Human) | |||||
Uniprot ID/ACC | P25774 (CATS_HUMAN) | |||||
Synonym(s) | - | |||||
Gene Symbol | CTSS | |||||
Gene ID | 1520 | |||||
Sequence | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI | |||||
Protein Class | HYDROLASE | |||||
Function | Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
COVPDB571 | BLN | 1MS6 | Kd : 0.3 nM, IC50 : 19 nM | BindingDB | SHOW | |
COVPDB601 | C1P | 1NPZ | Ki : 13 nM | PDBBind | SHOW | |
COVPDB601 | C1P | 1NPZ | IC50 : 1-1.2 nM | BindingDB | SHOW | |
COVPDB608 | C4P | 1NQC | Ki : 50 nM | PDBBind | SHOW | |
COVPDB753 | EF3 | 3N4C | IC50 : 9.5 nM | PDBBind | SHOW | |
COVPDB1167 | O64 | 3OVX | IC50 : 31 nM | PDBBind | SHOW | |
COVPDB1167 | O64 | 3OVX | IC50 : 31 nM | BindingDB | SHOW | |
COVPDB1384 | TF5 | 2OP3 | Ki : 490 nM | PDBBind | SHOW | |
COVPDB1480 | Y11 | 2R9M | IC50 : 1.5 nM, IC50 : 0.9 nM | BindingDB | SHOW | |
COVPDB603 | C28 | 2FT2 |
- |
- |
SHOW | |
COVPDB422 | 935 | 3N3G |
- |
- |
SHOW | |
COVPDB1481 | Y14 | 2R9N |
- |
- |
SHOW | |
COVPDB614 | C71 | 2FRQ |
- |
- |
SHOW | |
COVPDB653 | CRV | 2FRA |
- |
- |
SHOW | |
COVPDB1107 | MQQ | 2G6D |
- |
- |
SHOW | |
COVPDB1482 | Y15 | 2R9O |
- |
- |
SHOW | |
COVPDB652 | CRL | 2FUD |
- |
- |
SHOW | |
COVPDB547 | BCQ | 2FYE |
- |
- |
SHOW | |
COVPDB890 | H7J | 2HXZ |
- |
- |
SHOW | |
COVPDB651 | CRJ | 2FQ9 |
- |
- |
SHOW |