Protein
Protein Name Cathepsin S
#PDB ID 18
Organism Homo sapiens (Human)
Uniprot ID/ACC P25774 (CATS_HUMAN)
Synonym(s) -
Gene Symbol CTSS
Gene ID 1520
Sequence MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
Protein Class HYDROLASE
Function Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB571 BLN 1MS6 Kd : 0.3 nM, IC50 : 19 nM BindingDB SHOW
COVPDB601 C1P 1NPZ Ki : 13 nM PDBBind SHOW
COVPDB601 C1P 1NPZ IC50 : 1-1.2 nM BindingDB SHOW
COVPDB608 C4P 1NQC Ki : 50 nM PDBBind SHOW
COVPDB753 EF3 3N4C IC50 : 9.5 nM PDBBind SHOW
COVPDB1167 O64 3OVX IC50 : 31 nM PDBBind SHOW
COVPDB1167 O64 3OVX IC50 : 31 nM BindingDB SHOW
COVPDB1384 TF5 2OP3 Ki : 490 nM PDBBind SHOW
COVPDB1480 Y11 2R9M IC50 : 1.5 nM, IC50 : 0.9 nM BindingDB SHOW
COVPDB603 C28 2FT2
-
-
SHOW
COVPDB422 935 3N3G
-
-
SHOW
COVPDB1481 Y14 2R9N
-
-
SHOW
COVPDB614 C71 2FRQ
-
-
SHOW
COVPDB653 CRV 2FRA
-
-
SHOW
COVPDB1107 MQQ 2G6D
-
-
SHOW
COVPDB1482 Y15 2R9O
-
-
SHOW
COVPDB652 CRL 2FUD
-
-
SHOW
COVPDB547 BCQ 2FYE
-
-
SHOW
COVPDB890 H7J 2HXZ
-
-
SHOW
COVPDB651 CRJ 2FQ9
-
-
SHOW