| Protein Name |
17-beta-hydroxysteroid dehydrogenase type 1 |
| #PDB ID |
1
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
P14061 (DHB1_HUMAN)
|
| Synonym(s) |
- 17-beta-HSD 1
- 20 alpha-hydroxysteroid dehydrogenase
- estradiol 17-beta-dehydrogenase 1
- placental 17-beta-hydroxysteroid dehydrogenase
- short chain dehydrogenase/reductase family 28C member 1
- short chain dehydrogenase/reductase family 28CE
- member 1
- 17-beta-HSD
- 20-alpha-HSD
- E2DH
- EDH17B2
- EDHB17
- HSD17
- SDR28C1
show 13 synonym(s)
|
| Gene Symbol |
HSD17B1
|
| Gene ID |
3292
|
| Sequence |
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ |
| Protein Class |
OXIDOREDUCTASE |
| Function |
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH.
|
