| Protein Name |
Vitamin D3 receptor |
| #PDB ID |
2
|
| Organism |
Rattus norvegicus (Rat) |
| Uniprot ID/ACC |
P13053 (VDR_RAT)
|
| Synonym(s) |
- 1,25-dihydroxyvitamin D3 receptor
- nuclear receptor subfamily 1 group I member 1
- vitamin D (1,25- dihydroxyvitamin D3) receptor
- Nr1i1
show 3 synonym(s)
|
| Gene Symbol |
Vdr
|
| Gene ID |
24873
|
| Sequence |
MEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSSSSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNEIS |
| Protein Class |
SIGNALING PROTEIN |
| Function |
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:17227670). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (PubMed:17227670).
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