Protein
Protein Name Lysosomal protective protein
#PDB ID 1
Organism Homo sapiens (Human)
Uniprot ID/ACC P10619 (PPGB_HUMAN)
Synonym(s)
  •   beta-galactosidase 2
  • beta-galactosidase protective protein
  • carboxypeptidase C
  • carboxypeptidase Y-like kininase
  • carboxypeptidase-L
  • deamidase
  • lysosomal carboxypeptidase A
  • protective protein cathepsin A
  • urinary kininase
  • GLB2
  • GSL
  • NGBE
  • PPCA
  • PPGB
show 13 synonym(s)
Gene Symbol CTSA
Gene ID 5476
Sequence MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
Protein Class HYDROLASE
Function Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB317 6KZ 4CIA
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