| Protein Name |
Thymidylate synthase 1 |
| #PDB ID |
1
|
| Organism |
Bacillus subtilis (strain 168) |
| Uniprot ID/ACC |
P0CI79 (TYSY1_BACSU)
|
| Synonym(s) |
- thymidylate synthase A (phage origin)
- BSU_17680
- BSU17680
show 2 synonym(s)
|
| Gene Symbol |
thyA1
|
| Gene ID |
939555
|
| Sequence |
MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDGTIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVAV |
| Protein Class |
TRANSFERASE |
| Function |
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
|
