Protein
Protein Name Delta-aminolevulinic acid dehydratase
#PDB ID 3
Organism Escherichia coli (strain K12)
Uniprot ID/ACC P0ACB2 (HEM2_ECOLI)
Synonym(s)
  •   porphobilinogen synthase
  • AJR21_RS12445
  • AJR21_012650
show 2 synonym(s)
Gene Symbol hemB
Gene ID 58461832
Sequence MTDLIQRPRRLRKSPALRAMFEETTLSLNDLVLPIFVEEEIDDYKAVEAMPGVMRIPEKHLAREIERIANAGIRSVMTFGISHHTDETGSDAWREDGLVARMSRICKQTVPEMIVMSDTCFCEYTSHGHCGVLCEHGVDNDATLENLGKQAVVAAAAGADFIAPSAAMDGQVQAIRQALDAAGFKDTAIMSYSTKFASSFYGPFREAAGSALKGDRKSYQMNPMNRREAIRESLLDEAQGADCLMVKPAGAYLDIVRELRERTELPIGAYQVSGEYAMIKFAALAGAIDEEKVVLESLGSIKRAGADLIFSYFALDLAEKKILR
Protein Class LYASE
Function Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB714 DSB 1I8J IC50 : 39000 nM PDBBind SHOW
COVPDB714 DSB 1L6S IC50 : 39000 nM PDBBind SHOW
COVPDB1308 SHF 1B4E
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SHOW