Protein |
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| Protein Name | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | |||||
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| #PDB ID | 1 | |||||
| Organism | Escherichia coli (strain K12) | |||||
| Uniprot ID/ACC | P0A953 (FABB_ECOLI) | |||||
| Synonym(s) |
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| Gene Symbol | fabB | |||||
| Gene ID | 57728059 | |||||
| Sequence | MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD | |||||
| Protein Class | TRANSFERASE | |||||
| Function | Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor (PubMed:9013860, PubMed:8910376, PubMed:19679654, PubMed:22017312).Can also use unsaturated fatty acids (PubMed:3076377, PubMed:8910376, PubMed:19679654).Catalyzes a key reaction in unsaturated fatty acid (UFA) synthesis, the elongation of the cis-3-decenoyl-ACP produced by FabA (PubMed:19679654).Can use acyl chains from C-6 to C-14 (PubMed:9013860, PubMed:8910376, PubMed:19679654, PubMed:22017312).Has an absolute requirement for an ACP substrate as the acyl donor, and no activity is detected when both substrates are based on CoA (PubMed:22017312). |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
| COVPDB98 | CER | 1FJ8 |
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