| Protein Name |
Neutrophil elastase |
| #PDB ID |
2
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
P08246 (ELNE_HUMAN)
|
| Synonym(s) |
- PMN elastase
- bone marrow serine protease
- elastase 2
- neutrophil
- elastase-2
- granulocyte-derived elastase
- leukocyte elastase
- medullasin
- polymorphonuclear elastase
- polymorphonuclear leukocyte elastase
- ELA2
- GE
- HLE
- HNE
- NE
- PMN-E
- SCN1
show 16 synonym(s)
|
| Gene Symbol |
ELANE
|
| Gene ID |
1991
|
| Sequence |
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH |
| Protein Class |
HYDROLASE |
| Function |
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984).
|
