Protein
Protein Name Cholinesterase
#PDB ID 12
Organism Homo sapiens (Human)
Uniprot ID/ACC P06276 (CHLE_HUMAN)
Synonym(s)
  •   acylcholine acylhydrolase
  • butyrylcholine esterase
  • choline esterase II
  • cholinesterase (serum) 2
  • cholinesterase 1
  • pseudocholinesterase
  • BCHED
  • CHE1
  • CHE2
  • E1
show 9 synonym(s)
Gene Symbol BCHE
Gene ID 590
Sequence MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
Protein Class HYDROLASE
Function Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB1378 TC3 2WIG Kd : 370000 nM PDBBind SHOW
COVPDB1380 TC5 2WIK Kd : 660000 nM PDBBind SHOW
COVPDB1391 TN7 2WIJ Kd : 630000 nM PDBBind SHOW
COVPDB754 EFS 1XLV
-
-
SHOW
COVPDB1452 VX 2XQK
-
-
SHOW
COVPDB959 ISP 1XLU
-
-
SHOW
COVPDB589 BUA 1P0I
-
-
SHOW
COVPDB754 EFS 2WSL
-
-
SHOW
COVPDB1452 VX 2XQF
-
-
SHOW
COVPDB1390 TN6 2WIF
-
-
SHOW
COVPDB1390 TUN 2WID
-
-
SHOW
COVPDB1452 VX 2XQJ
-
-
SHOW