Protein
Protein Name Coagulation factor XI
#PDB ID 12
Organism Homo sapiens (Human)
Uniprot ID/ACC P03951 (FA11_HUMAN)
Synonym(s)
  •   coagualtion factor XI
  • plasma thromboplastin antecedent
  • FXI
  • PTA
show 3 synonym(s)
Gene Symbol F11
Gene ID 2160
Sequence MIFLYQVVHFILFTSVSGECVTQLLKDTCFEGGDITTVFTPSAKYCQVVCTYHPRCLLFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQAV
Protein Class HYDROLASE
Function Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB173 339 1ZOM IC50 : 30 nM PDBBind SHOW
COVPDB173 339 1ZOM IC50 : 30 nM BindingDB SHOW
COVPDB299 682 2FDA IC50 : 502 nM PDBBind SHOW
COVPDB429 995 1ZPB IC50 : 850 nM PDBBind SHOW
COVPDB954 INH 3BG8 IC50 : 1300 nM PDBBind SHOW
COVPDB213 412 1ZML
-
-
SHOW
COVPDB291 62A 1ZTK
-
-
SHOW
COVPDB216 427 1ZMN
-
-
SHOW
COVPDB591 BUK 1ZPZ
-
-
SHOW
COVPDB177 368 1ZLR
-
-
SHOW
COVPDB292 632 1ZTJ
-
-
SHOW
COVPDB899 HDB 1ZMJ
-
-
SHOW
COVPDB290 624 1ZSL
-
-
SHOW