Protein
Protein Name Protein S100-B
#PDB ID 2
Organism Bos taurus (Bovine)
Uniprot ID/ACC P02638 (S100B_BOVIN)
Synonym(s)
  •   S-100 protein beta chain
  • S-100 protein subunit beta
  • S100 protein
  • beta polypeptide
show 3 synonym(s)
Gene Symbol S100B
Gene ID 525716
Sequence MSELEKAVVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDSDGDGECDFQEFMAFVAMITTACHEFFEHE
Protein Class CELL CYCLE
Function Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity).
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB1177 ODN 4PE7
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COVPDB1278 REV 4PE4
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SHOW