| Protein Name |
Complement factor D |
| #PDB ID |
3
|
| Organism |
Homo sapiens (Human) |
| Uniprot ID/ACC |
P00746 (CFAD_HUMAN)
|
| Synonym(s) |
- C3 convertase activator
- D component of complement (adipsin)
- complement factor D preproprotein
- properdin factor D
- ADIPSIN
- ADN
- DF
- PFD
show 7 synonym(s)
|
| Gene Symbol |
CFD
|
| Gene ID |
1675
|
| Sequence |
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA |
| Protein Class |
HYDROLASE |
| Function |
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
|
