Protein
Protein Name Retinal dehydrogenase 1
#PDB ID 1
Organism Homo sapiens (Human)
Uniprot ID/ACC P00352 (AL1A1_HUMAN)
Synonym(s)
  •   ALDH class 1
  • ALHDII
  • RALDH 1
  • acetaldehyde dehydrogenase 1
  • aldehyde dehydrogenase 1
  • soluble
  • aldehyde dehydrogenase
  • liver cytosolic
  • epididymis luminal protein 12
  • epididymis luminal protein 9
  • epididymis secretory sperm binding protein Li 53e
  • retinaldehyde dehydrogenase 1
  • ALDC
  • ALDH-E1
  • ALDH1
  • ALDH11
  • HEL-9
  • HEL-S-53e
  • HEL12
  • PUMB1
  • RALDH1
show 20 synonym(s)
Gene Symbol ALDH1A1
Gene ID 216
Sequence MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS
Protein Class OXIDOREDUCTASE
Function Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:19296407, PubMed:26373694, PubMed:25450233).
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB1017 K9P 5AC2
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