Protein
Protein Name Cathepsin S
#PDB ID 6
Organism Mus musculus (Mouse)
Uniprot ID/ACC O70370 (CATS_MOUSE)
Synonym(s)
  •   Cat S
  • Cats
show 1 synonym(s)
Gene Symbol Ctss
Gene ID 13040
Sequence MRAPGHAAIRWLFWMPLVCSVAMEQLQRDPTLDYHWDLWKKTHEKEYKDKNEEEVRRLIWEKNLKFIMIHNLEYSMGMHTYQVGMNDMGDMTNEEILCRMGALRIPRQSPKTVTFRSYSNRTLPDTVDWREKGCVTEVKYQGSCGACWAFSAVGALEGQLKLKTGKLISLSAQNLVDCSNEEKYGNKGCGGGYMTEAFQYIIDNGGIEADASYPYKATDEKCHYNSKNRAATCSRYIQLPFGDEDALKEAVATKGPVSVGIDASHSSFFFYKSGVYDDPSCTGNVNHGVLVVGYGTLDGKDYWLVKNSWGLNFGDQGYIRMARNNKNHCGIASYCSYPEI
Protein Class HYDROLASE
Function Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB131 2EV 4MZS IC50 : 12 nM PDBBind SHOW
COVPDB132 2EW 4MZO IC50 : 271 nM PDBBind SHOW
COVPDB1091 MG2 4BS5 IC50 : 6 nM PDBBind SHOW
COVPDB1264 QQV 4BSQ IC50 : 0.7 nM PDBBind SHOW
COVPDB987 JG7 4BS6
-
-
SHOW
COVPDB404 8PW 4BQV
-
-
SHOW