Protein |
||||||
| Protein Name | Cocaine esterase | |||||
|---|---|---|---|---|---|---|
| #PDB ID | 7 | |||||
| Organism | Rhodococcus sp. (strain MB1 Bresler) | |||||
| Uniprot ID/ACC | Q9L9D7 (COCE_RHOSM) | |||||
| Synonym(s) | - | |||||
| Gene Symbol | cocE | |||||
| Gene ID | - | |||||
| Sequence | MVDGNYSVASNVMVPMRDGVRLAVDLYRPDADGPVPVLLVRNPYDKFDVFAWSTQSTNWLEFVRDGYAVVIQDTRGLFASEGEFVPHVDDEADAEDTLSWILEQAWCDGNVGMFGVSYLGVTQWQAAVSGVGGLKAIAPSMASADLYRAPWYGPGGALSVEALLGWSALIGTGLITSRSDARPEDAADFVQLAAILNDVAGAASVTPLAEQPLLGRLIPWVIDQVVDHPDNDESWQSISLFERLGGLATPALITAGWYDGFVGESLRTFVAVKDNADARLVVGPWSHSNLTGRNADRKFGIAATYPIQEATTMHKAFFDRHLRGETDALAGVPKVRLFVMGIDEWRDETDWPLPDTAYTPFYLGGSGAANTSTGGGTLSTSISGTESADTYLYDPADPVPSLGGTLLFHNGDNGPADQRPIHDRDDVLCYSTEVLTDPVEVTGTVSARLFVSSSAVDTDFTAKLVDVFPDGRAIALCDGIVRMRYRETLVNPTLIEAGEIYEVAIDMLATSNVFLPGHRIMVQVSSSNFPKYDRNSNTGGVIAREQLEEMCTAVNRIHRGPEHPSHIVLPIIKR | |||||
| Protein Class | HYDROLASE | |||||
| Function | Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants. Also efficiently hydrolyzes cocaethylene, a more potent cocaine metabolite that has been observed in patients who concurrently abuse cocaine and alcohol. Is able to prevent cocaine-induced convulsions and lethality in rat. |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
| COVPDB682 | DBC | 3I2G |
- |
- |
 |
SHOW |
| COVPDB682 | DBC | 3IDA |
- |
- |
|
SHOW |
| COVPDB682 | DBC | 3I2I |
- |
- |
|
SHOW |
| COVPDB682 | DBC | 3I2F |
- |
- |
|
SHOW |
| COVPDB1216 | PBC | 1JU3 |
- |
- |
 |
SHOW |
| COVPDB682 | DBC | 3I2H |
- |
- |
|
SHOW |
| COVPDB682 | DBC | 3I2K |
- |
- |
|
SHOW |