Protein |
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| Protein Name | Sortase B | |||||
|---|---|---|---|---|---|---|
| #PDB ID | 2 | |||||
| Organism | Staphylococcus aureus (strain NCTC 8325 / PS 47) | |||||
| Uniprot ID/ACC | Q2FZE3 (SRTB_STAA8) | |||||
| Synonym(s) |
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| Gene Symbol | srtB | |||||
| Gene ID | 3919249 | |||||
| Sequence | MRMKRFLTIVQILLVVIIIIFGYKIVQTYIEDKQERANYEKLQQKFQMLMSKHQEHVRPQFESLEKINKDIVGWIKLSGTSLNYPVLQGKTNHDYLNLDFEREHRRKGSIFMDFRNELKNLNHNTILYGHHVGDNTMFDVLEDYLKQSFYEKHKIIEFDNKYGKYQLQVFSAYKTTTKDNYIRTDFENDQDYQQFLDETKRKSVINSDVNVTVKDRIMTLSTCEDAYSETTKRIVVVAKIIKVS | |||||
| Protein Class | HYDROLASE | |||||
| Function | Transpeptidase that anchors surface proteins to the cell wall (PubMed:11830639, PubMed:15718231, PubMed:24519933) (Probable). Recognizes and modifies its substrate by proteolytic cleavage of a C-terminal sorting signal. Following cleavage, a covalent intermediate is formed via a thioester bond between the sortase and its substrate, which is then transferred and covalently attached to the cell wall (Probable) (PubMed:24519933). This sortase recognizes an Asn-Pro-Gln-Thr-Asn (NPQTN) motif in IsdC, which is cleaved by the sortase between the threonine and aspargine residues; may only have 1 substrate in this bacterium (Probable). May be dedicated to the process of iron acquisition during bacterial infection (Probable). |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
| COVPDB769 | ETM | 1QWZ |
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- |
 |
SHOW |
| COVPDB769 | ETM | 1QXA |
- |
- |
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SHOW |