Protein |
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Protein Name | Cruzipain | |||||
---|---|---|---|---|---|---|
#PDB ID | 17 | |||||
Organism | Trypanosoma cruzi | |||||
Uniprot ID/ACC | P25779 (CYSP_TRYCR) | |||||
Synonym(s) | - | |||||
Gene Symbol | - | |||||
Gene ID | - | |||||
Sequence | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSYFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL | |||||
Protein Class | HYDROLASE | |||||
Function | Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle. |
Bound Ligands |
Ligand ID | HET Code | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
COVPDB69 | 186 | 1U9Q | IC50 : 4.7 nM | PDBBind | SHOW | |
COVPDB69 | 186 | 1U9Q | Ki : 1102.9 nM | Binding MOAD | SHOW | |
COVPDB116 | 25B | 3HD3 | IC50 : 100 nM | PDBBind | SHOW | |
COVPDB234 | 4MC | 3LXS | IC50 : 8 nM | PDBBind | SHOW | |
COVPDB672 | D1R | 2OZ2 | Kd : 1930 nM | PDBBind | SHOW | |
COVPDB1026 | KB2 | 3IUT | Ki : 460 nM | PDBBind | SHOW | |
COVPDB1259 | QL2 | 3I06 | IC50 : 0.2-10 nM, IC50 : 0.2 nM, IC50 : 10 nM | BindingDB | SHOW | |
COVPDB1512 | ZYA | 1AIM |
- |
- |
SHOW | |
COVPDB1506 | ZRA | 2AIM |
- |
- |
SHOW | |
COVPDB1450 | VSC | 1EWO |
- |
- |
SHOW | |
COVPDB1274 | R99 | 1EWL |
- |
- |
SHOW | |
COVPDB1447 | VS2 | 1F2A |
- |
- |
SHOW | |
COVPDB20 | 0I5 | 1EWP |
- |
- |
SHOW | |
COVPDB160 | 2V5 | 4PI3 |
- |
- |
SHOW | |
COVPDB1448 | VS3 | 1F2B |
- |
- |
SHOW | |
COVPDB1446 | VS1 | 1F29 |
- |
- |
SHOW | |
COVPDB1283 | RL2 | 1EWM |
- |
- |
SHOW | |
COVPDB1449 | VS4 | 1F2C |
- |
- |
SHOW |