Protein
Protein Name Cruzipain
#PDB ID 17
Organism Trypanosoma cruzi
Uniprot ID/ACC P25779 (CYSP_TRYCR)
Synonym(s) -
Gene Symbol -
Gene ID -
Sequence MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSYFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
Protein Class HYDROLASE
Function Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
Bound Ligands
Ligand ID HET Code PDB ID Binding Affinity Binding Database Structure Complex Card
COVPDB69 186 1U9Q IC50 : 4.7 nM PDBBind SHOW
COVPDB69 186 1U9Q Ki : 1102.9 nM Binding MOAD SHOW
COVPDB116 25B 3HD3 IC50 : 100 nM PDBBind SHOW
COVPDB234 4MC 3LXS IC50 : 8 nM PDBBind SHOW
COVPDB672 D1R 2OZ2 Kd : 1930 nM PDBBind SHOW
COVPDB1026 KB2 3IUT Ki : 460 nM PDBBind SHOW
COVPDB1259 QL2 3I06 IC50 : 0.2-10 nM, IC50 : 0.2 nM, IC50 : 10 nM BindingDB SHOW
COVPDB1512 ZYA 1AIM
-
-
SHOW
COVPDB1506 ZRA 2AIM
-
-
SHOW
COVPDB1450 VSC 1EWO
-
-
SHOW
COVPDB1274 R99 1EWL
-
-
SHOW
COVPDB1447 VS2 1F2A
-
-
SHOW
COVPDB20 0I5 1EWP
-
-
SHOW
COVPDB160 2V5 4PI3
-
-
SHOW
COVPDB1448 VS3 1F2B
-
-
SHOW
COVPDB1446 VS1 1F29
-
-
SHOW
COVPDB1283 RL2 1EWM
-
-
SHOW
COVPDB1449 VS4 1F2C
-
-
SHOW