Ligand
Ligand Name:   MG132
Ligand Type:   non-polymer
Ligand ID:   COVPDB496 PubChem:   462382
Synonym(s):  
  •   mg-132
  • 133407-82-6
  • z-leu-leu-leu-al
  • mg 132
  • zlllal
  • z-lll-cho
  • zlll-cho
  • z-leu-leu-leucinal
  • z-leu-leu-leu-h
  • carbobenzoxy-leucyl-leucyl-leucinal
  • unii-rf1p63gw3k
  • benzyloxycarbonyl-leu-leu-leu-aldehyde
  • benzyloxycarbonyl-leucyl-leucyl-leucinal
  • carbobenzoxyl-leucinyl-leucinyl-leucinal-h
  • cbz-leu-leu-leu-h
  • c26h41n3o5
  • benzyloxycarbonylleucyl-leucyl-leucine aldehyde
  • z-leu-leu-leu-aldehyde
  • rf1p63gw3k
  • carbobenzoxy-l-leucyl-l-leucyl-l-leucinal
  • chembl64925
  • benzyl (s)-4-methyl-1-((s)-4-methyl-1-((s)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate
  • cbz-l-leu-l-leu-l-leu-cho
  • chebi:75142
  • mfcd00674886
  • benzyl ((s)-4-methyl-1-(((s)-4-methyl-1-(((s)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate
  • lll cpd
  • (s)-n-((phenylmethoxy)carbonyl)-l-leucyl-n-(1-formyl-3-methylbutyl)-l-leucinamide
  • n-[(benzyloxy)carbonyl]-l-leucyl-n-[(2s)-4-methyl-1-oxopentan-2-yl]-l-leucinamide
  • brd0970
  • brd-0970
  • z-lll
  • (r)-mg132
  • (s)-mg132
  • n-[(benzyloxy)carbonyl]-l-leucyl-n-[(1s)-1-formyl-3-methylbutyl]-l-leucinamide
  • z-lll-aldehyde
  • n-[(phenylmethoxy)carbonyl]-l-leucyl-n-[(1s)-1-formyl-3-methylbutyl]-l-leucinamide
  • 1211877-36-9
  • benzyl n-[(1s)-3-methyl-1-[[(1s)-3-methyl-1-[[(2s)-4-methyl-1-oxo-pentan-2-yl]carbamoyl]butyl]carbamoyl]butyl]carbamate
  • z-lllal
  • cbz-leu-leu-leu-al
  • cbz-leu-leu-leucinal
  • z-lll-h
  • z-l-leu-l-leu-l-leu-h
  • bspbio_001310
  • carbobenzoxy-leu-leu-leucinal
  • kbiogr_000030
  • kbioss_000030
  • cc-245
  • mls006011220
  • cbz-l-leu-l-leu-l-leu-h
  • schembl160925
  • gtpl8616
  • dtxsid3042639
  • bcbcmap01_000028
  • kbio2_000030
  • kbio2_002598
  • kbio2_005166
  • kbio3_000059
  • kbio3_000060
  • aob4946
  • qcr-183
  • benzyloxycarbonyl-leu-leu-leucinal
  • bio2_000030
  • bio2_000510
  • hms1361b12
  • hms1791b12
  • hms1989b12
  • hms3402b12
  • amy40914
  • ex-a1500
  • abp000958
  • bdbm50069985
  • nsc782153
  • pi-102
  • s2619
  • zinc13476439
  • akos027420457
  • mg132/mg-132/
  • acn-047884
  • ccg-207860
  • ccg-208036
  • cs-0471
  • nsc-782153
  • sb19111
  • compound 5b [pmid: 16686537]
  • idi1_033780
  • ncgc00161679-01
  • ncgc00161679-02
  • ncgc00161679-03
  • ncgc00161679-04
  • z-leu-leu-leu-al, >=90% (hplc)
  • as-55854
  • hy-13259
  • smr002530629
  • ab0033810
  • sw219780-1
  • unm000011053701
  • x7579
  • w-5117
  • insolution mg-132 - cas 133407-82-6
  • n-benzyloxycarbonyl-l-leucyl-l-leucyl-l-leucinal
  • q3272916
  • sr-01000864598-1
  • brd-k60230970-001-04-3
  • brd-k60230970-001-05-0
  • brd-k60230970-001-06-8
  • brd-k60230970-001-07-6
  • brd-k60230970-001-08-4
  • brd-k60230970-001-10-0
  • mg-132 - cas 133407-82-6
  • mg-132, >/=95% by hplc - cas 133407-82-6
  • l-leucinamide, n-((phenylmethoxy)carbonyl)-l-leucyl-n-((1s)-1-formyl-3-methylbutyl)-
  • l-leucinamide, n-((phenylmethoxy)carbonyl)-l-leucyl-n-(1-formyl-3-methylbutyl)-, (s)-
  • l-leucinamide, n-[(phenylmethoxy)carbonyl]-l-leucyl-n1-[(1s)-1-formyl-3-methylbutyl]-
  • n-[(phenylmethoxy)carbonyl]-l-leucyl-n-(1-formyl-3-methylbutyl)-(s)-l-leucinamide
  • (s)-4-methyl-2-(3-phenyl-propionylamino)-pentanoic acid [(s)-1-((s)-1-formyl-3-methyl-butylcarbamoyl)-3-methyl-butyl]-amide
  • {(s)-1-[(s)-1-((s)-1-formyl-3-methyl-butylcarbamoyl)-3-methyl-butylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester
  • {1-[(s)-(s)-1-((s)-1-formyl-3-methyl-butylcarbamoyl)-3-methyl-butylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester
  • {1-[1-(1-formyl-3-methyl-butylcarbamoyl)-3-methyl-butylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester
  • benzyl n-[(1s)-1-[[(1s)-1-[[(1s)-1-formyl-3-methyl-butyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]carbamate
  • benzyl(s)-4-methyl-1-((s)-4-methyl-1-((s)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxopentan-2-ylcarbamate
  • phenylmethyl n-[(2s)-4-methyl-1-[[(2s)-4-methyl-1-[[(2s)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
show 122 synonym(s)
DrugBank:   - ChEMBL:   CHEMBL64925
Canonical SMILES:   CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Standard InChI:   InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
Molecular Formula:   C26H41N3O5 Mol. Weight:   475.30463 logP:   3.5882
HBD:   3 HBA:   5
#Rotatable Bonds:   14 TPSA:   113.6

Bound Proteins
Protein Name Uniprot ID/ACC Organism PDB ID HET Code Binding Affinity Binding Database Complex Card
Proteasome subunit beta type-1 P38624 (PSB1_YEAST) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 4NNN ALD IC50 : 270 nM PDBBind SHOW
Papain P00784 (PAPA1_CARPA) Carica papaya (Papaya) 1BP4 ALD
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