Ligand
Ligand Name:   N-(3,5-dichloro-2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)phenyl)acrylamide
Ligand Type:   non-polymer
Ligand ID:   COVPDB1466 PubChem:   134457612
Synonym(s):  
  •   chembl4086669
  • schembl20094102
  • bdbm50233452
show 2 synonym(s)
DrugBank:   - ChEMBL:   CHEMBL4086669
Canonical SMILES:   COc1cc(OC)c(Cl)c(c1Cl)COc2cnc(nc2)Nc3c(NC(=O)C=C)cc(Cl)cc3Cl
Standard InChI:   InChI=1S/C22H18Cl4N4O4/c1-4-18(31)29-15-6-11(23)5-14(24)21(15)30-22-27-8-12(9-28-22)34-10-13-19(25)16(32-2)7-17(33-3)20(13)26/h4-9H,1,10H2,2-3H3,(H,29,31)(H,27,28,30)
Molecular Formula:   C22H18Cl4N4O4 Mol. Weight:   542.00824 logP:   6.5545
HBD:   2 HBA:   7
#Rotatable Bonds:   9 TPSA:   94.6

Bound Proteins
Protein Name Uniprot ID/ACC Organism PDB ID HET Code Binding Affinity Binding Database Complex Card
Fibroblast growth factor receptor 4 P22455 (FGFR4_HUMAN) Homo sapiens (Human) 6NVG XL8
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