Protein

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Protein Name Muscarinic acetylcholine receptor M2
#PDB ID 8
Organism Homo sapiens
Uniprot ID/ACC P08172 (ACM2_HUMAN)
Protein Sequence MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
Protein Class SIGNALING PROTEIN
Synonym(s)
  •   muscarinic acetylcholine receptor M2
  • 7TM receptor
  • acetylcholine receptor, muscarinic 2
  • muscarinic M2 receptor
  • HM2
show 4 synonym(s)
Gene Symbol CHRM2
Gene ID 1129
Pfam ID PF00001
Interpro ID IPR000276, IPR017452, IPR001065, IPR000995
Bound Ligands
HET ID Ligand Type PDB ID Binding Affinity Binding Database Structure Complex Card
IXO Small Molecule 4MQS Ki : 2.5 nM, Ki : 10.0 nM, Ki : 257.0 nM, Ki : 2.2 nM, Ki : 4.9 nM, Ki : 8.7 nM, EC50 : 0.17 nM, EC50 : 0.08 nM, EC50 : 0.28 nM BindingDB SHOW
IXO Small Molecule 4MQT Ki : 8.7 nM, Ki : 257.0 nM, Ki : 2.5 nM, Ki : 10.0 nM, Ki : 4.9 nM, Ki : 2.2 nM, EC50 : 0.08 nM, EC50 : 0.17 nM, EC50 : 0.28 nM BindingDB SHOW
3C0 Small Molecule 5ZKC Kd : 6.4 nM Binding MOAD SHOW
3C0 Small Molecule 5YC8 Kd : 6.4 nM Binding MOAD SHOW
QNB Small Molecule 3UON
-
-
SHOW
QNB Small Molecule 5ZK3
-
-
SHOW
3C0 Small Molecule 5ZK8
-
-
SHOW
IXO Small Molecule 6OIK
-
-
SHOW