Protein Download |
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Protein Name | Acetylcholinesterase | |||||
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#PDB ID | 14 | |||||
Organism | Homo sapiens | |||||
Uniprot ID/ACC | P22303 (ACES_HUMAN) | |||||
Protein Sequence | MRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQDRCSDL | |||||
Protein Class | HYDROLASE | |||||
Synonym(s) |
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Gene Symbol | ACHE | |||||
Gene ID | 43 | |||||
Pfam ID | PF08674, PF00135 | |||||
Interpro ID | IPR029058, IPR014788, IPR002018, IPR019826, IPR019819, IPR000997 |
Bound Ligands |
HET ID | Ligand Type | PDB ID | Binding Affinity | Binding Database | Structure | Complex Card |
E20 | Small Molecule | 4EY7 | IC50 : 5.3 nM, IC50 : 120.0 nM, IC50 : 160.0 nM, IC50 : 26.8 nM, IC50 : 5.0 nM, IC50 : 8.2 nM, IC50 : 2.0 nM, IC50 : 6.9 nM, IC50 : 3.5 nM, IC50 : 13.0 nM, IC50 : 1.7 nM, IC50 : 0.12 nM, IC50 : 11.0 nM, IC50 : 12.0 nM, IC50 : 7.9 nM, IC50 : 35.48 nM, IC50 : 19.0 nM, IC50 : 20.0 nM, IC50 : 6.0 nM, IC50 : 4.2 nM, IC50 : 15.0 nM, IC50 : 16.0 nM, IC50 : 7.0 nM, IC50 : 2.3 nM, IC50 : 23.1 nM, IC50 : 8.0 nM, IC50 : 21.5 nM, IC50 : 22.0 nM, IC50 : 9.0 nM, IC50 : 19.0 nM, IC50 : 10.0 nM, IC50 : 8.12 nM, IC50 : 11.0 nM, IC50 : 37.0 nM, IC50 : 40.0 nM, IC50 : 12.0 nM, IC50 : 32.0 nM, IC50 : 14.0 nM, IC50 : 15.0 nM, IC50 : 16.0 nM, IC50 : 18.0 nM, IC50 : 19.0 nM, EC50 : 43.0 nM, IC50 : 20.0 nM, IC50 : 22.0 nM, IC50 : 23.0 nM, IC50 : 6.0 nM, IC50 : 30.0 nM, IC50 : 32.0 nM, IC50 : 36.0 nM, IC50 : 38.0 nM, IC50 : 94.0 nM, IC50 : 40.0 nM, IC50 : 41.0 nM, IC50 : 48.0 nM, IC50 : 50.0 nM, IC50 : 6.16 nM, IC50 : 5.7 nM, IC50 : 5.7 nM, IC50 : 11.6 nM, IC50 : 0.02 nM, IC50 : 62.0 nM, IC50 : 8.0 nM, IC50 : 90.0 nM, Ki : 2.9 nM, Ki : 38.0 nM, Ki : 7.2 nM, Ki : 10.0 nM, Ki : 20.5 nM, Ki : 21.0 nM, Ki : 2.9 nM, Ki : 26.0 nM | BindingDB | SHOW | |
E20 | Small Molecule | 6O4W |
- |
- |
SHOW | |
HI6 | Small Molecule | 6NTM |
- |
- |
SHOW | |
L0S | Small Molecule | 6NTH |
- |
- |
SHOW | |
EBW | Small Molecule | 6O52 |
- |
- |
SHOW | |
PQY | Small Molecule | 6U3P |
- |
- |
SHOW | |
PQV | Small Molecule | 6U34 |
- |
- |
SHOW | |
L2Y | Small Molecule | 6NTO |
- |
- |
SHOW | |
HLO | Small Molecule | 6NEA |
- |
- |
SHOW | |
HI6 | Small Molecule | 6NTN |
- |
- |
SHOW | |
EBW | Small Molecule | 6O50 |
- |
- |
SHOW | |
L0S | Small Molecule | 6NTK |
- |
- |
SHOW | |
HI6 | Small Molecule | 6NTG |
- |
- |
SHOW | |
L1M | Small Molecule | 6NTL |
- |
- |
SHOW |