Protein

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Protein Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A
#PDB ID 1
Organism Homo sapiens
Uniprot ID/ACC P27815 (PDE4A_HUMAN)
Protein Sequence MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
Protein Class HYDROLASE
Synonym(s)
  •   phosphodiesterase 4A, cAMP-specific (dunce
  • phosphodiesterase E2 dunce homolog, Drosophila
  • phosphodiesterase isozyme 4
  • DPDE2
  • PDE4
  • PDE46
show 5 synonym(s)
Gene Symbol PDE4A
Gene ID 5141
Pfam ID PF18100, PF00233
Interpro ID IPR003607, IPR040844, IPR023088, IPR002073, IPR036971, IPR023174
Bound Ligands
HET ID Ligand Type PDB ID Binding Affinity Binding Database Structure Complex Card
0MO Small Molecule 3I8V IC50 : 4300.0 nM, EC50 : 3300.0 nM, IC50 : 4800.0 nM, IC50 : 26000.0 nM BindingDB SHOW