Index Protein Name Organism UniProt ID/ACC #Protein-Ligand Complex(es) 1 14-3-3 protein sigma Homo sapiens (Human) P31947/1433S_HUMAN 11 2 2-hydroxymuconate tautomerase Pseudomonas putida (Arthrobacter siderocapsulatus) Q01468/4OT1_PSEPU 1 3 3C-like proteinase Middle East respiratory syndrome-related coronavirus (MERS-CoV) V9TU12/V9TU12_MERS 1 4 Albumin Homo sapiens (Human) P02768/ALBU_HUMAN 2 5 Aldehyde dehydrogenase, dimeric NADP-preferring Homo sapiens (Human) P30838/AL3A1_HUMAN 2 6 Aldehyde dehydrogenase, mitochondrial Homo sapiens (Human) P05091/ALDH2_HUMAN 1 7 Aminotransferase Escherichia coli O44:H18 (strain 042 / EAEC) D3H0F7/D3H0F7_ECO44 2 8 Baculoviral IAP repeat-containing protein 2 Homo sapiens (Human) Q13490/BIRC2_HUMAN 1 9 Beta-lactamase Bacillus licheniformis P00808/BLAC_BACLI 12 10 Camphor 5-monooxygenase Pseudomonas putida (Arthrobacter siderocapsulatus) P00183/CPXA_PSEPU 2 11 Caspase-3 Homo sapiens (Human) P42574/CASP3_HUMAN 19 12 Caspase-8 Homo sapiens (Human) Q14790/CASP8_HUMAN 3 13 Cathepsin B1 isotype 1 Schistosoma mansoni (Blood fluke) Q8MNY2/Q8MNY2_SCHMA 4 14 Cathepsin F Homo sapiens (Human) Q9UBX1/CATF_HUMAN 1 15 Cathepsin K Homo sapiens (Human) P43235/CATK_HUMAN 38 16 Cathepsin L2 Homo sapiens (Human) O60911/CATL2_HUMAN 1 17 Cathepsin S Homo sapiens (Human) P25774/CATS_HUMAN 18 18 Coagulation factor XIII A chain Homo sapiens (Human) P00488/F13A_HUMAN 3 19 Cruzipain Trypanosoma cruzi P25779/CYSP_TRYCR 17 20 Cyclin-dependent kinase 2 Homo sapiens (Human) P24941/CDK2_HUMAN 8 21 Cysteine protease Trypanosoma brucei rhodesiense Q95PM0/Q95PM0_TRYBR 2 22 Cytoplasmic tyrosine-protein kinase BMX Homo sapiens (Human) P51813/BMX_HUMAN 1 23 Dihydroorotate dehydrogenase (fumarate) Trypanosoma cruzi (strain CL Brener) Q4D3W2/PYRD_TRYCC 2 24 Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens (Human) Q02750/MP2K1_HUMAN 1 25 Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens (Human) O14733/MP2K7_HUMAN 8 26 E3 ubiquitin-protein ligase RNF31 Homo sapiens (Human) Q96EP0/RNF31_HUMAN 6 27 Epidermal growth factor receptor Homo sapiens (Human) P00533/EGFR_HUMAN 15 28 Estrogen receptor Homo sapiens (Human) P03372/ESR1_HUMAN 2 29 Exportin-1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) P30822/XPO1_YEAST 12 30 Ferritin light chain Equus caballus (Horse) P02791/FRIL_HORSE 3 31 Fibroblast growth factor receptor 1 Homo sapiens (Human) P11362/FGFR1_HUMAN 5 32 Fibroblast growth factor receptor 4 Homo sapiens (Human) P22455/FGFR4_HUMAN 14 33 Gag-Pol polyprotein Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) P03366/POL_HV1B1 3 34 Genome polyprotein Human enterovirus D68 (EV68) (EV-68) A1E4A3/A1E4A3_HED68 7 35 Genome polyprotein Human enterovirus 71 (EV71) (EV-71) A9XG43/A9XG43_HE71 12 36 Genome polyprotein Coxsackievirus A16 C8CIL7/C8CIL7_9ENTO 1 37 Genome polyprotein Human enterovirus 71 (EV71) (EV-71) E0WWC7/E0WWC7_HE71 1 38 Genome polyprotein Human enterovirus 71 (EV71) (EV-71) E7E815/E7E815_HE71 3 39 Genome polyprotein Echovirus 1 (strain Human/Egypt/Farouk/1951) (E-1) O91734/POLG_EC01F 1 40 Genome polyprotein Coxsackievirus B3 (strain Nancy) P03313/POLG_CXB3N 1 41 Genome polyprotein Human rhinovirus 2 (HRV-2) P04936/POLG_HRV2 1 42 Genome polyprotein Hepatitis C virus genotype 1b (isolate BK) (HCV) P26663/POLG_HCVBK 4 43 Genome polyprotein Southampton virus (strain GI/Human/United Kingdom/Southampton/1991) (SHV) (Hu/NV/SHV/1991/UK) Q04544/POLG_SOUV3 1 44 Genome polyprotein Enterovirus B Q5DSM6/Q5DSM6_9ENTO 2 45 Genome polyprotein Coxsackievirus B3 Q5UEA2/Q5UEA2_9ENTO 9 46 Glutathione S-transferase omega-1 Homo sapiens (Human) P78417/GSTO1_HUMAN 7 47 Glycogen synthase kinase-3 beta Homo sapiens (Human) P49841/GSK3B_HUMAN 1 48 GTPase HRas Homo sapiens (Human) P01112/RASH_HUMAN 9 49 GTPase KRas Homo sapiens (Human) P01116/RASK_HUMAN 43 50 GTPase KRas isoform X2 Erinaceus europaeus (Western European hedgehog) A0A1S2ZE25/A0A1S2ZE25_ERIEU 1 51 Hemoglobin subunit alpha Homo sapiens (Human) P69905/HBA_HUMAN 12 52 Hemoglobin subunit beta Homo sapiens (Human) P68871/HBB_HUMAN 2 53 Histidine--tRNA ligase Trypanosoma cruzi (strain CL Brener) Q4DA54/Q4DA54_TRYCC 1 54 Isocitrate dehydrogenase [NADP] cytoplasmic Homo sapiens (Human) O75874/IDHC_HUMAN 4 55 Isocitrate lyase Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) P9WKK7/ACEA_MYCTU 1 56 Kelch-like ECH-associated protein 1 Homo sapiens (Human) Q14145/KEAP1_HUMAN 3 57 L,D-transpeptidase 2 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) I6Y9J2/LDT2_MYCTU 15 58 Lysine-specific demethylase 5A Homo sapiens (Human) P29375/KDM5A_HUMAN 3 59 Lysine-specific demethylase 5B Homo sapiens (Human) Q9UGL1/KDM5B_HUMAN 1 60 Methionine aminopeptidase Escherichia coli C3TPN7/C3TPN7_ECOLX 1 61 Mitogen-activated protein kinase 1 Homo sapiens (Human) P28482/MK01_HUMAN 5 62 Mitogen-activated protein kinase 1 Rattus norvegicus (Rat) P63086/MK01_RAT 1 63 Mitogen-activated protein kinase 14 Homo sapiens (Human) Q16539/MK14_HUMAN 2 64 Mitogen-activated protein kinase 3 Homo sapiens (Human) P27361/MK03_HUMAN 1 65 N-lysine methyltransferase KMT5A Homo sapiens (Human) Q9NQR1/KMT5A_HUMAN 3 66 Nuclear receptor subfamily 4 group A member 2 Homo sapiens (Human) P43354/NR4A2_HUMAN 2 67 O-GlcNAcase BT_4395 Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) Q89ZI2/OGA_BACTN 4 68 Ornithine aminotransferase Toxoplasma gondii (strain ATCC 50611 / Me49) S8EY38/S8EY38_TOXGM 1 69 Papain Carica papaya (Papaya) P00784/PAPA1_CARPA 5 70 Peroxisome proliferator-activated receptor gamma Homo sapiens (Human) P37231/PPARG_HUMAN 14 71 Phosphate-binding protein PstS Escherichia coli (strain K12) P0AG82/PSTS_ECOLI 1 72 Proline racemase A Trypanosoma cruzi (strain CL Brener) Q4DA80/PRCMA_TRYCC 2 73 Protease Human adenovirus D serotype 8 (HAdV-8) (Human adenovirus 8) B9A5C1/B9A5C1_ADE08 4 74 Proteinaceous RNase P 1, chloroplastic/mitochondrial Arabidopsis thaliana (Mouse-ear cress) Q66GI4/PRRP1_ARATH 4 75 Protein S100-B Bos taurus (Bovine) P02638/S100B_BOVIN 2 76 Proto-oncogene tyrosine-protein kinase Src Gallus gallus (Chicken) P00523/SRC_CHICK 11 77 Pyridoxal 5'-phosphate synthase subunit PDX1.1 Arabidopsis thaliana (Mouse-ear cress) O80448/PDX11_ARATH 1 78 Pyridoxal 5'-phosphate synthase subunit PDX1.3 Arabidopsis thaliana (Mouse-ear cress) Q8L940/PDX13_ARATH 4 79 Queuine tRNA-ribosyltransferase Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) P28720/TGT_ZYMMO 1 80 RAC-alpha serine/threonine-protein kinase Homo sapiens (Human) P31749/AKT1_HUMAN 3 81 Replicase polyprotein 1a Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) P0C6T4/R1A_BCHK4 1 82 Replicase polyprotein 1a Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) P0C6U3/R1A_CVHN1 1 83 Replicase polyprotein 1a Severe acute respiratory syndrome coronavirus (SARS-CoV) P0C6U8/R1A_SARS 10 84 Replicase polyprotein 1a Avian infectious bronchitis virus (strain M41) (IBV) P0C6V5/R1A_IBVM 1 85 Replicase polyprotein 1a Porcine epidemic diarrhea virus (strain CV777) (PEDV) P0C6V6/R1A_PEDV7 1 86 Replicase polyprotein 1ab Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) Q98VG9/R1AB_FIPV 2 87 Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus (SARS-CoV) P0C6X7/R1AB_SARS 19 88 Replicase polyprotein 1ab Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) P0DTD1/R1AB_SARS2 83 89 Ribosomal protein S6 kinase alpha-3 Mus musculus (Mouse) P18654/KS6A3_MOUSE 1 90 Ribosomal protein S6 kinase alpha-3 Homo sapiens (Human) P51812/KS6A3_HUMAN 2 91 SUMO-activating enzyme subunit 2 Homo sapiens (Human) Q9UBT2/SAE2_HUMAN 1 92 T-box transcription factor T Homo sapiens (Human) O15178/TBXT_HUMAN 1 93 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Homo sapiens (Human) Q15750/M3K7_HUMAN 6 94 Thioredoxin Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) P9WG67/THIO_MYCTU 1 95 Thymidylate synthase Lactobacillus casei P00469/TYSY_LACCA 1 96 Thymidylate synthase Pneumocystis carinii P13100/TYSY_PNECA 1 97 Thymidylate synthase Homo sapiens (Human) P04818/TYSY_HUMAN 1 98 Thymidylate synthase Mus musculus (Mouse) P07607/TYSY_MOUSE 2 99 Thymidylate synthase Escherichia coli (strain K12) P0A884/TYSY_ECOLI 13 100 Thymidylate synthase Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) P0CS12/TYSY_CRYNJ 1 101 Transcriptional regulator, PadR-like family Lactococcus lactis subsp. cremoris (strain MG1363) A2RI36/A2RI36_LACLM 1 102 Transforming protein RhoA Homo sapiens (Human) P61586/RHOA_HUMAN 1 103 Transthyretin Homo sapiens (Human) P02766/TTHY_HUMAN 9 104 Tubulin alpha-1B chain Bos taurus (Bovine) P81947/TBA1B_BOVIN 1 105 Tubulin beta-2B chain Bos taurus (Bovine) Q6B856/TBB2B_BOVIN 5 106 Tubulinyl-Tyr carboxypeptidase 1 Homo sapiens (Human) Q7L8A9/VASH1_HUMAN 2 107 Tyrosine-protein kinase BTK Homo sapiens (Human) Q06187/BTK_HUMAN 14 108 Tyrosine-protein kinase ITK/TSK Homo sapiens (Human) Q08881/ITK_HUMAN 4 109 Tyrosine-protein kinase JAK3 Homo sapiens (Human) P52333/JAK3_HUMAN 9 110 Tyrosine-protein phosphatase YopH Yersinia enterocolitica P15273/YOPH_YEREN 2 111 Ubiquitin carboxyl-terminal hydrolase 7 Homo sapiens (Human) Q93009/UBP7_HUMAN 1 112 Ubiquitin-conjugating enzyme E2 N Homo sapiens (Human) P61088/UBE2N_HUMAN 2 113 UPF0678 fatty acid-binding protein-like protein At1g79260 Arabidopsis thaliana (Mouse-ear cress) O64527/Y1926_ARATH 1 114 Urease subunit alpha Sporosarcina pasteurii (Bacillus pasteurii) P41020/URE1_SPOPA 2 115 Vitamin D3 receptor Rattus norvegicus (Rat) P13053/VDR_RAT 2 116 Ypt/Rab-type GTPase YPT7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) P32939/YPT7_YEAST 2